Any feedback?
Literature summary for 2.1.1.37 extracted from
- The recognition pathway for the DNA cytosine methyltransferase M.HhaI (2009), Biochemistry, 48, 7807-7816.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA + S-adenosyl-L-methionine | Haemophilus haemolyticus | - |
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Haemophilus haemolyticus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA + S-adenosyl-L-methionine | - |
Haemophilus haemolyticus | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
| DNA + S-adenosyl-L-methionine | cytosine DNA methyltransferase M.HhaI modifies the internal cytosine within its cognate recognition site 5'-GCGC-3'. Binding of either unmethylated or hemimethylated cognate DNA to the cofactor-bound binary complex leads to dramatic changes in the 1H-15N correlation spectrum, analysis of hemimethylated and methylated, cognate and noncognate substrate binding , detailed overview | Haemophilus haemolyticus | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
| additional information | reorganization of an essential catalytic loop, residues 80-100, is regulated by sequence-specific protein-DNA interactions, DNA-dependent positioning of the catalytic loop | Haemophilus haemolyticus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DNA cytosine methyltransferase | - |
Haemophilus haemolyticus |
| M.HhaI | - |
Haemophilus haemolyticus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| S-adenosyl-L-methionine | binding of either unmethylated or hemimethylated cognate DNA to the cofactor-bound binary complex leads to dramatic changes in the 1H-15N correlation spectrum | Haemophilus haemolyticus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
