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Literature summary for 2.1.1.366 extracted from
- Histone H3K9 methyltransferase SETDB1 augments invadopodia formation to promote tumor metastasis (2022), Oncogene, 41, 3370-3380.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | O88974 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lung adenocarcinoma cell | - |
Mus musculus | - |
| non-small cell lung cancer cell | - |
Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| histone H3K9 methyltransferase | - |
Mus musculus |
| SETDB1 | - |
Mus musculus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | upregulation in non-small cell lung cancer | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | SETDB1 strengthens non-small cell lung cancer cell migratory and invasive abilities by promoting invadopodia formation and extracellular matrix degradation. At the molecular level, SETDB1 suppresses the expression of FOXA2, a crucial tumor and metastasis suppressor via coordinated epigenetic mechanisms. SETDB1 not only catalyzes histone H3K9 methylation on FOXA2 genomic locus, but also recruits DNMT3A to regulate DNA methylation on CpG island. Setdb1 is essential for malignant progression and metastasis of murine lung adenocarcinoma | Mus musculus |
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