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Literature summary for 2.1.1.366 extracted from

  • Hu, L.; Cheng, Z.; Wu, L.; Luo, L.; Pan, P.; Li, S.; Jia, Q.; Yang, N.; Xu, B.
    Histone methyltransferase SETDB1 promotes osteogenic differentiation in osteoporosis by activating OTX2-mediated BMP-Smad and Wnt/beta-catenin pathways (2023), Hum. Cell, 36, 1373-1388.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus O88974
-
-

Source Tissue

Source Tissue Comment Organism Textmining
femur
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?

Synonyms

Synonyms Comment Organism
SETDB1
-
 Mus musculus

General Information

General Information Comment Organism
physiological function SETDB1 methylation regulates H3K9me3 in the OTX2 promoter region and inhibits the expression of OTX2. SETDB1 expression is downregulated in osteoporotic femoral tissues and is involved in osteogenic differentiation. Upregulation of SETDB1 promotes osteogenic differentiation by inhibiting OTX2 and activating the BMP-Smad and Wnt/beta-catenin pathways in osteoporosis Mus musculus