Literature summary for 2.1.1.366 extracted from

Singh, S.K.; Bahal, R.; Rasmussen, T.P.
Evidence that miR-152-3p is a positive regulator of SETDB1-mediated H3K9 histone methylation and serves as a toggle between histone and DNA methylation (2020), Exp. Cell Res., 395, 112216 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q15047	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hep-G2 cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	microRNA, miR-152-3p is involved in the regulation of SETDB1 protein levels and plays a positive regulatory role for SETDB1 expression. Inhibition of miR-152-3p results in a robust reduction in SETDB1 protein levels, though SETDB1 mRNA levels are unaffected. This is accompanied by a blockade of the biochemical pathway proceeding from H3K9me2 to H3K9me3. H3K9me2 accumulates in cells treated with an anti-miR that targets miR-152-3p. The action of a miR-152-3p mimic increases flux of the reaction leading to H3K9me3	Homo sapiens

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Release 2023.1 (January 2023)