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Literature summary for 2.1.1.366 extracted from

  • Singh, S.K.; Bahal, R.; Rasmussen, T.P.
    Evidence that miR-152-3p is a positive regulator of SETDB1-mediated H3K9 histone methylation and serves as a toggle between histone and DNA methylation (2020), Exp. Cell Res., 395, 112216.
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q15047
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-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
histone methyltransferase SETDB1
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens miR-152 expression has a positive effect on SETDB1 protein expression and enzyme activity up

General Information

General Information Comment Organism
physiological function microRNA, miR-152-3p is involved in the regulation of SETDB1 protein levels and plays a positive regulatory role for SETDB1 expression. Inhibition of miR-152-3p results in a robust reduction in SETDB1 protein levels, though SETDB1 mRNA levels are unaffected. This is accompanied by a blockade of the biochemical pathway proceeding from H3K9me2 to H3K9me3. H3K9me2 accumulates in cells treated with an anti-miR that targets miR-152-3p. The action of a miR-152-3p mimic increases flux of the reaction leading to H3K9me3 Homo sapiens
physiological function SETDB1 is a major enzyme for H3K9 histone methylation in heterochromatin Homo sapiens