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Literature summary for 2.1.1.366 extracted from

  • Mochizuki, K.; Tando, Y.; Sekinaka, T.; Otsuka, K.; Hayashi, Y.; Kobayashi, H.; Kamio, A.; Ito-Matsuoka, Y.; Takehara, A.; Kono, T.; Osumi, N.; Matsui, Y.
    SETDB1 is essential for mouse primordial germ cell fate determination by ensuring BMP signaling (2018), Development, 145, dev164160.
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Mus musculus O88974
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Source Tissue

Source Tissue Comment Organism Textmining
embryo
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 Mus musculus
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General Information

General Information Comment Organism
physiological function SETDB1 is an epigenetic regulator of primordial germ cell fate determination. SETDB1-deficient embryos exhibit drastic reduction of nascent primordial germ cells. Dppa2, Otx2 and Utf1 are derepressed whereas mesoderm development-related genes, including BMP4 signaling-related genes, are downregulated by SETDB1 knockdown during primordial germ cell-like cell induction. Binding of SETDB1 is observed at the flanking regions of Dppa2, Otx2 and Utf1 in cell aggregates containing primordial germ cell-like cell induction, and trimethylation of lysine 9 of histone H3 is reduced by SETDB1 knockdown at those regions Mus musculus