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Literature summary for 2.1.1.366 extracted from

  • Fatima, A.; Irmak, D.; Noormohammadi, A.; Rinschen, M.M.; Das, A.; Leidecker, O.; Schindler, C.; Sanchez-Gaya, V.; Wagle, P.; Pokrzywa, W.; Hoppe, T.; Rada-Iglesias, A.; Vilchez, D.
    The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells (2020), Commun. Biol., 3, 262.
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q15047
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Source Tissue

Source Tissue Comment Organism Textmining
embryo embryonic stem cell Homo sapiens
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embryonic stem cell
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function embryonic stem cells exhibit high expression of the ubiquitin-conjugating enzyme UBE2K. Loss of UBE2K upregulates the trimethyltransferase SETDB1, resulting in H3K9 trimethylation and repression of neurogenic genes during differentiation Homo sapiens