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Literature summary for 2.1.1.366 extracted from
- Histone methyltransferase SETDB1 maintains survival of mouse spermatogonial stem/progenitor cells via PTEN/AKT/FOXO1 pathway (2017), Biochim. Biophys. Acta, 1860, 1094-1102.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | O88974 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| spermatogonium | spermatogonial stem cell | Mus musculus | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | SETDB1 regulates the PTEN/AKT/FOXO1 pathway to inhibit spermatogonial stem cell apoptosis. SETDB1 interacts and coordinates with AKT to regulate FOXO1 activity and expression of the downstream target genes Bim and Puma. Among the SETDB1-bound genes, the H3K9me3 levels on the promoter regions of Bim and Pten decrease in the SETDB1-knock down group. The H3K9me3 status on promoters of Bax and Puma remains unchanged | Mus musculus |
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