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Literature summary for 2.1.1.366 extracted from

  • Hachiya, R.; Shiihashi, T.; Shirakawa, I.; Iwasaki, Y.; Matsumura, Y.; Oishi, Y.; Nakayama, Y.; Miyamoto, Y.; Manabe, I.; Ochi, K.; Tanaka, M.; Goda, N.; Sakai, J.; Suganami, T.; Ogawa, Y.
    The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages (2016), Sci. Rep., 6, 28845 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus O88974
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-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
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 Mus musculus
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Synonyms

Synonyms Comment Organism
SETDB1
-
 Mus musculus

General Information

General Information Comment Organism
physiological function Setdb1 in macrophages potently suppresses Toll-like receptor TLR4-mediated expression of proinflammatory cytokines including interleukin-6 through its methyltransferase activity. Setdb1-deficiency decreases the basal H3K9 methylation levels and augments TLR4-mediated NF-kappaB recruitment on the proximal promoter region of interleukin-6, thereby accelerating interleukin-6 promoter activity. Macrophage-specific Setdb1-knockout mice exhibit higher serum interleukin-6 concentrations in response to lipopolysaccharide challenge and are more susceptible to endotoxin shock than wild-type mice Mus musculus