Literature summary for 2.1.1.364 extracted from

Ko, S.; Ahn, J.; Song, C.; Kim, S.; Knapczyk-Stwora, K.; Chatterjee, B.
Lysine methylation and functional modulation of androgen receptor by set9 methyltransferase (2011), Mol. Endocrinol., 25, 433-444 .

Search for more literature for 2.1.1.364

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8WTS6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
C4-2 cell	-	Homo sapiens	-
LNCaP cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + [androgen receptor]-L-lysine630	-	Homo sapiens	S-adenosyl-L-homocysteine + [androgen receptor]-N6-methyl-L-lysine630	-	?

Synonyms

Synonyms	Comment	Organism
SET9	-	Homo sapiens
SetD7	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	Set9 methylates the nuclear and cytoplasmic androgen receptor. Set9 overexpression potentiates androgen receptor-mediated transactivation of the probasin promoter, whereas Set9 depletion inhibits androgen receptor activity and target gene expression. Chromatin occupancy of Set9 at androgen response elements is androgen dependent, and associated with methylated histone H3K4 chromatin activation marks and p300/CBP associated factor acetyltransferase recruitment. Set9 depletion increases the histone H3K9-dimethyl repressive mark at androgen response elements and reduces histone activation marks and occupancy of p300/CBP associated factor. K630A mutation of the androgen receptor reduces amino- and carboxy-terminal interaction in Set9-intact cells, whereas amino- and carboxy-terminal interaction for wild-type androgen receptor is reduced upon Set9 depletion	Homo sapiens

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Release 2023.1 (January 2023)