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Literature summary for 2.1.1.364 extracted from

  • Elkouris, M.; Kontaki, H.; Stavropoulos, A.; Antonoglou, A.; Nikolaou, K.; Samiotaki, M.; Szantai, E.; Saviolaki, D.; Brown, P.; Sideras, P.; Panayotou, G.; Talianidis, I.
    SET9-mediated regulation of TGF-beta signaling links protein methylation to pulmonary fibrosis (2016), Cell Rep., 15, 2733-2744 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus Q8VHL1
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + [Smad7]-L-lysine70
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 Mus musculus S-adenosyl-L-homocysteine + [Smad7]-N6-methyl-L-lysine70
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 ?

General Information

General Information Comment Organism
physiological function methyltransferase Set9 potentiates TGF-beta signaling by targeting Smad7, an inhibitory downstream effector. Smad7 methylation promotes interaction with the E3 ligase Arkadia and, thus, ubiquitination-dependent degradation. Depletion or pharmacological inhibition of Set9 results in elevated Smad7 protein levels and inhibits TGF-beta-dependent expression of genes encoding extracellular matrix components. Lung fibrosis induced by bleomycin or Ad-TGF-beta treatment is highly compromised in Set9-deficient mice Mus musculus