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Literature summary for 2.1.1.364 extracted from

  • Li, Y.; Reddy, M.A.; Miao, F.; Shanmugam, N.; Yee, J.K.; Hawkins, D.; Ren, B.; Natarajan, R.
    Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation (2008), J. Biol. Chem., 283, 26771-26781.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Homo sapiens
-
monocyte
-
 Homo sapiens
-
THP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + histone H3(K4)
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
chromatin histone H3-lysine 4 methyltransferase
-
 Homo sapiens
H3-K4 HMT
-
 Homo sapiens
SET7/9
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the expression of SET7/9 is not altered by tissue necrosis factor-alpha treatment additional information

General Information

General Information Comment Organism
malfunction SET7/9 deficiency does not affect p65 DNA binding as assessed by electrophoretic mobility shift assays, S100b-induced gene expression is decreased by SET7/9 knockdown Homo sapiens
physiological function SET7/9 may act as a transcriptional cofactor of NF-kappaB p65, SET7/9 may regulate NF-kappaB-dependent genes through modifications of chromatin histone lysine at these specific gene promoters, SET7/9 is recruited to the promoters of inflammatory genes and enhances p65 recruitment to these gene promoters, SET7/9 is not involved in monocyte differentiation but affects monocyte adhesion Homo sapiens