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Literature summary for 2.1.1.364 extracted from

  • Hu, P.; Zhang, Y.
    Catalytic mechanism and product specificity of the histone lysine methyltransferase SET7/9: an ab initio QM/MM-FE study with multiple initial structures (2006), J. Am. Chem. Soc., 128, 1272-1278.
    View publication on PubMed

Application

Application Comment Organism
analysis multiple ab initio quantum mechanical/molecular mechanical free energy calculations and molecular dynamics simulations for the investigation of the methyl-transfer reaction catalyzed by SET7/9 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information methyl-transfer reaction catalyzed by SET7/9 is a typical in-line SN2 nucleophilic substitution reaction with a transition state of 70% dissociative character, transfers only one methyl group to the unmodified histone-lysine residue H3-K4 Homo sapiens ?
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Synonyms

Synonyms Comment Organism
histone lysine methyltransferase SET7/9
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Homo sapiens