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Literature summary for 2.1.1.361 extracted from

  • Weirich, S.; Kusevic, D.; Kudithipudi, S.; Jeltsch, A.
    Investigation of the methylation of Numb by the SET8 protein lysine methyltransferase (2015), Sci. Rep., 5, 13813 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.361

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells or HEK-293 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a [histone H4]-L-lysine20 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
 ?
S-adenosyl-L-methionine + [p53]-L-lysine382 Homo sapiens
-
 S-adenosyl-L-homocysteine + [p53]-N6-methyl-L-lysine382
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NQR1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no methylation of Numb protein by the enzyme is detectable Homo sapiens ?
-
 ?
S-adenosyl-L-methionine + a [histone H4]-L-lysine20
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
 ?
S-adenosyl-L-methionine + [p53]-L-lysine382
-
 Homo sapiens S-adenosyl-L-homocysteine + [p53]-N6-methyl-L-lysine382
-
 ?

Synonyms

Synonyms Comment Organism
PKMT
-
 Homo sapiens
protein lysine methyltransferase
-
 Homo sapiens
SET8
-
 Homo sapiens