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Literature summary for 2.1.1.361 extracted from

  • Xiao, B.; Jing, C.; Kelly, G.; Walker, P.A.; Muskett, F.W.; Frenkiel, T.A.; Martin, S.R.; Sarma, K.; Reinberg, D.; Gamblin, S.J.; Wilson, J.R.
    Specificity and mechanism of the histone methyltransferase Pr-Set7 (2005), Genes Dev., 19, 1444-1454 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.361

Crystallization (Commentary)

Crystallization (Comment) Organism
ternary enzyme complex with a 10-mer peptide based on histone H4 (RHRK(Me1)VLRDNY) and the cofactor product S-adenosyl-L-homocysteine, vapor diffusion method, using 100 mM PIPES (pH 7.0), 100 mM KSCN with 30% (w/v) MePEG 2000 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleosome
-
 Homo sapiens 786
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a [histone H4]-L-lysine20 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + a [histone H4]-L-lysine20
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
 ?
S-adenosyl-L-methionine + SGRGKGGKGLGKGGAKRHRKVLRDNIQGIY
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
histone 4 K20 methyltransferase
-
 Homo sapiens
Pr-Set7
-
 Homo sapiens
SET8
-
 Homo sapiens