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Literature summary for 2.1.1.361 extracted from

  • Chen, X.; Ding, X.; Wu, Q.; Qi, J.; Zhu, M.; Miao, C.
    Monomethyltransferase SET8 facilitates hepatocellular carcinoma growth by enhancing aerobic glycolysis (2019), Cell Death Dis., 10, 312 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine upregulation of the enzyme is positively correlated with a poor survival rate in hepatocellular carcinoma patients Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a [histone H4]-L-lysine20 Homo sapiens
-
S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NQR1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocellular carcinoma cell
-
Homo sapiens
-
MHCC-LM3 cell
-
Homo sapiens
-
MHCC97-H cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + a [histone H4]-L-lysine20
-
Homo sapiens S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
-
?

Synonyms

Synonyms Comment Organism
KMT5a
-
Homo sapiens
Pr-Set7
-
Homo sapiens
SET8
-
Homo sapiens
SETD8
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is upregulated in hepatocellular carcinoma up

General Information

General Information Comment Organism
malfunction enzyme deficiency confers an impaired glucose metabolism phenotype and thus inhibits the progression of hepatocellular carcinoma tumors Homo sapiens
physiological function the enzyme facilitates hepatocellular carcinoma growth by enhancing aerobic glycolysis. The enzyme directly binds to and inactivates KLF4 Homo sapiens