Application | Comment | Organism |
---|---|---|
medicine | upregulation of the enzyme is positively correlated with a poor survival rate in hepatocellular carcinoma patients | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + a [histone H4]-L-lysine20 | Homo sapiens | - |
S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NQR1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocellular carcinoma cell | - |
Homo sapiens | - |
MHCC-LM3 cell | - |
Homo sapiens | - |
MHCC97-H cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + a [histone H4]-L-lysine20 | - |
Homo sapiens | S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
KMT5a | - |
Homo sapiens |
Pr-Set7 | - |
Homo sapiens |
SET8 | - |
Homo sapiens |
SETD8 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme is upregulated in hepatocellular carcinoma | up |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme deficiency confers an impaired glucose metabolism phenotype and thus inhibits the progression of hepatocellular carcinoma tumors | Homo sapiens |
physiological function | the enzyme facilitates hepatocellular carcinoma growth by enhancing aerobic glycolysis. The enzyme directly binds to and inactivates KLF4 | Homo sapiens |