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Literature summary for 2.1.1.361 extracted from

  • Tryndyak, V.P.; Kovalchuk, O.; Pogribny, I.P.
    Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins (2006), Cancer Biol. Ther., 5, 65-70 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H4]-L-lysine20 Homo sapiens
-
 3 S-adenosyl-L-homocysteine + a [histone H4]-N6,N6,N6-trimethyl-L-lysine20
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86Y97
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
MCF-10-2A cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H4]-L-lysine20
-
 Homo sapiens 3 S-adenosyl-L-homocysteine + a [histone H4]-N6,N6,N6-trimethyl-L-lysine20
-
 ?

Synonyms

Synonyms Comment Organism
Suv4-20h2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme expression is down-regulated in breast cancer cells down