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Literature summary for 2.1.1.360 extracted from

  • Ogoh, H.; Yamagata, K.; Nakao, T.; Sandell, L.; Yamamoto, A.; Yamashita, A.; Tanga, N.; Suzuki, M.; Abe, T.; Kitabayashi, I.; Watanabe, T.; Sakai, D.
    Mllt10 knockout mouse model reveals critical role of Af10-dependent H3K79 methylation in midfacial development (2017), Sci. Rep., 7, 11922 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.360

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 Mus musculus overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
additional information Mus musculus AF10 bound to the enzyme simultaneously senses unmodified histone H3 lysine 27 via its PHD finger-Zn knuckle-PHD finger domain and enables the enzyme to methylate histone H3 at lysine 79. Knockout embryos, lacking Af10, have reduced [histone H3]-N6-methyl-L-lysine79 in developing nasal processes and reduced expression of AP2alpha, a gene required for cranial neural crest cell development ?
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine79 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine79 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine79 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine79
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 overall reaction Mus musculus 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
additional information AF10 bound to the enzyme simultaneously senses unmodified histone H3 lysine 27 via its PHD finger-Zn knuckle-PHD finger domain and enables the enzyme to methylate histone H3 at lysine 79. Knockout embryos, lacking Af10, have reduced [histone H3]-N6-methyl-L-lysine79 in developing nasal processes and reduced expression of AP2alpha, a gene required for cranial neural crest cell development Mus musculus ?
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine79
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine79
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine79
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine79
-
 ?

Synonyms

Synonyms Comment Organism
DOT1L
-
 Mus musculus