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Literature summary for 2.1.1.360 extracted from

  • Li, T.; Liu, Q.; Garza, N.; Kornblau, S.; Jin, V.
    Integrative analysis reveals functional and regulatory roles of H3K79me2 in mediating alternative splicing (2018), Genome Med., 10, 30 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.360

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 Homo sapiens overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine79 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine79 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine79 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine79
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8TEK3
-
-

Source Tissue

Source Tissue Comment Organism Textmining
GM-12878 cell
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-
MM1-S cell
-
 Homo sapiens
-
MOLM-14 cell
-
 Homo sapiens
-
MV-4-11 cell
-
 Homo sapiens
-
OCI-LY7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 overall reaction Homo sapiens 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine79
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine79
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine79
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine79
-
 ?

Synonyms

Synonyms Comment Organism
DOT1L
-
 Homo sapiens
K79me methyltransferase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme deletion impedes leukemia cell proliferation as well as switches exon skipping to the inclusion isoform in MLL-rearranged acute myeloid leukemia cell lines Homo sapiens
physiological function the enzyme is the major regulator in mediating skipping exon in MLL-rearranged acute myeloid leukemia progression Homo sapiens