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Literature summary for 2.1.1.360 extracted from

  • Wen, L.; Fu, L.; Guo, X.; Chen, Y.; Shi, Y.B.
    Histone methyltransferase Dot1L plays a role in postembryonic development in Xenopus tropicalis (2015), FASEB J., 29, 385-393 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.360

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 Xenopus tropicalis overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine79 Xenopus tropicalis
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine79 Xenopus tropicalis
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine79 Xenopus tropicalis
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine79
-
 ?

Organism

Organism UniProt Comment Textmining
Xenopus tropicalis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 overall reaction Xenopus tropicalis 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine79
-
 Xenopus tropicalis S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine79
-
 Xenopus tropicalis S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine79
-
 Xenopus tropicalis S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine79
-
 ?

Synonyms

Synonyms Comment Organism
DOT1L
-
 Xenopus tropicalis

Expression

Organism Comment Expression
Xenopus tropicalis enzyme expression is up-regulated around stage 22 and reaches high levels after stage 30 of postembryonic development up

General Information

General Information Comment Organism
malfunction enzyme knockdown severely retards the growth of the tadpoles and leads to tadpole lethality prior to metamorphosis Xenopus tropicalis
physiological function the enzyme plays an important role for tadpole growth and development prior to metamorphosis into a frog Xenopus tropicalis