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Literature summary for 2.1.1.360 extracted from

  • Evanno, E.; Godet, J.; Piccirilli, N.; Guilhot, J.; Milin, S.; Gombert, J.; Fouchaq, B.; Roche, J.
    Tri-methylation of H3K79 is decreased in TGF-beta1-induced epithelial-to-mesenchymal transition in lung cancer (2017), Clin. Epigenetics, 9, 80 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.360

Inhibitors

Inhibitors Comment Organism Structure
EPZ5676
-
 Homo sapiens
SGC0946
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 Homo sapiens overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8TEK3
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
lung cancer cell
-
 Homo sapiens
-
NCI-H358 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 overall reaction Homo sapiens 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
-
 ?

Synonyms

Synonyms Comment Organism
DOT1L
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens after a 48 h treatment with transforming growth factor beta1, the enzyme expression is decreased at the mRNA and protein levels down