Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.360 extracted from

  • Figueiredo, L.M.; Janzen, C.J.; Cross, G.A.
    A histone methyltransferase modulates antigenic variation in African trypanosomes (2008), PLoS Biol., 6, e161.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-
Trypanosoma brucei Lister 427
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + histone H3(K76)
-
Trypanosoma brucei ?
-
?
S-adenosyl-L-methionine + histone H3(K76)
-
Trypanosoma brucei Lister 427 ?
-
?

Synonyms

Synonyms Comment Organism
DOT1B
-
Trypanosoma brucei

General Information

General Information Comment Organism
malfunction transcriptionally silent telomeric variant surface glycoproteins become partially derepressed when DOT1B is deleted, whereas nontelomeric loci are unaffected Trypanosoma brucei
physiological function DOT1B is required to maintain strict variant surface glycoproteins silencing and to ensure rapid transcriptional variant surface glycoproteins switching Trypanosoma brucei