BRENDA - Enzyme Database
show all sequences of 2.1.1.358

Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling

Hu, M.; Sun, X.J.; Zhang, Y.L.; Kuang, Y.; Hu, C.Q.; Wu, W.L.; Shen, S.H.; Du, T.T.; Li, H.; He, F.; Xiao, H.S.; Wang, Z.G.; Liu, T.X.; Lu, H.; Huang, Q.H.; Chen, S.J.; Chen, Z.; Proc. Natl. Acad. Sci. USA 107, 2956-2961 (2010)

Data extracted from this reference:

Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
embryo
-
Mus musculus
-
endothelial cell
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + histone H3(K36)
-
720909
Mus musculus
?
-
-
-
?
S-adenosyl-L-methionine + histone H3(K36)
-
720909
Homo sapiens
?
-
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
embryo
-
Mus musculus
-
endothelial cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + histone H3(K36)
-
720909
Mus musculus
?
-
-
-
?
S-adenosyl-L-methionine + histone H3(K36)
-
720909
Homo sapiens
?
-
-
-
?
General Information
General Information
Commentary
Organism
malfunction
human endothelial cells with siRNA-mediated suppression of HYPB, show defects in cell migration, tubule formation, and invasion during vessel formation
Homo sapiens
malfunction
homozygous disruption of Hypb impairs histone H3(K36) trimethylation but not mono- or dimethylation, and resulted in embryonic lethality at E10.5-E11.5. Severe vascular defects are observed in the Hypb-deficient embryo, yolk sac, and placenta
Mus musculus
physiological function
histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling
Homo sapiens
physiological function
histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling
Mus musculus
General Information (protein specific)
General Information
Commentary
Organism
malfunction
human endothelial cells with siRNA-mediated suppression of HYPB, show defects in cell migration, tubule formation, and invasion during vessel formation
Homo sapiens
malfunction
homozygous disruption of Hypb impairs histone H3(K36) trimethylation but not mono- or dimethylation, and resulted in embryonic lethality at E10.5-E11.5. Severe vascular defects are observed in the Hypb-deficient embryo, yolk sac, and placenta
Mus musculus
physiological function
histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling
Homo sapiens
physiological function
histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling
Mus musculus
Other publictions for EC 2.1.1.358
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
720909
Hu
Histone H3 lysine 36 methyltra ...
Homo sapiens, Mus musculus
Proc. Natl. Acad. Sci. USA
107
2956-2961
2010
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