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Literature summary for 2.1.1.357 extracted from

  • Poulin, M.; Schneck, J.; Matico, R.; McDevitt, P.; Huddleston, M.; Hou, W.; Johnson, N.; Thrall, S.; Meek, T.; Schramm, V.
    Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36 (2016), Proc. Natl. Acad. Sci. USA, 113, 1197-1201 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.357

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 insect cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Homo sapiens overall reaction 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Homo sapiens
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 Homo sapiens preferred reaction S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O96028
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione Sepharose column chromatography, Mono S cation exchange column chromatography, and Superdex S200 gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 overall reaction Homo sapiens 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 preferred reaction Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Synonyms

Synonyms Comment Organism
MMSET
-
 Homo sapiens
NSD2
-
 Homo sapiens
nuclear receptor SET domain containing protein 2
-
 Homo sapiens
Whsc1
-
 Homo sapiens