Literature summary for 2.1.1.357 extracted from

Eram, M.S.; Kuznetsova, E.; Li, F.; Lima-Fernandes, E.; Kennedy, S.; Chau, I.; Arrowsmith, C.H.; Schapira, M.; Vedadi, M.
Kinetic characterization of human histone H3 lysine 36 methyltransferases, ASH1L and SETD2 (2015), Biochim. Biophys. Acta, 1850, 1842-1848.

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00003	-	recombinant nucleosome	pH 9.0, 23°C	Homo sapiens
0.00027	-	chicken nucleosome	pH 9.0, 23°C	Homo sapiens
0.0028	-	S-adenosyl-L-methionine	cosubstrate recombinant nucleosome, pH 9.0, 23°C	Homo sapiens
0.0038	-	S-adenosyl-L-methionine	cosubstrate chicken nucleosome, pH 9.0, 23°C	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NR48	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme mono- and dimethylates H3K36 and is inactive with H3K4 as substrate. Nucleosome containing histone H3 mutant K36A or histone H3 peptide 18-44 are not substrates. Isoform SETD2 is able to trimethylate H3K36 in vitro	Homo sapiens	?	-	?
S-adenosyl-L-methionine + chicken nucleosome	-	Homo sapiens	S-adenosyl-L-homocysteine + chicken nucleosome N6-methyl-L-lysine	-	?
S-adenosyl-L-methionine + histone H3(K36)	-	Homo sapiens	S-adenosyl-L-homocysteine + histone H3(K36) N6-methyl-L-lysine	-	?
S-adenosyl-L-methionine + recombinant nucleosome	-	Homo sapiens	S-adenosyl-L-homocysteine + recombinant nucleosome N6-methyl-L-lysine	-	?

Synonyms

Synonyms	Comment	Organism
Ash1L	-	Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.0001	-	recombinant nucleosome	pH 9.0, 23°C	Homo sapiens
0.0031	-	chicken nucleosome	pH 9.0, 23°C	Homo sapiens

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Release 2023.1 (January 2023)