Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.356 extracted from

  • Morishita, M.; Mevius, D.; Di Luccio, E.
    In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1 and NSD3/WHSC1L (2014), BMC Struct. Biol., 14, 25 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.356

Cloned(Commentary)

Cloned (Comment) Organism
expression of the C-terminal domain in Escherichia coli Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
molecular modelling of the open-and-closed conformation of the catalytic domain Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O96028 isoform NSD2
-
Homo sapiens Q9BZ95 cf. EC 2.1.1.371
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme shows versatility in substrate recognition. In a pan-methylation assay of histone H3, H3K4me3 and H3K27me3 species are preferably detected rather than me1 and me2 species, and H3K79-me1 and -me2 species are favored against me3 species. NSD3 shows significant di-/tri-methylation of histone H4K20 Homo sapiens ?
-
-
additional information enzyme shows versatility in substrate recognition. In a pan-methylation assay of histone H3, H3K4me3 and H3K27me3 species are preferably detected rather than me1 and me2 species, while H3K9-me1 and -me2 and H3K79-me1 and -me2 species are favored against me3 species. NSD2 shows di-/tri-methylation of histone H4K20 Homo sapiens ?
-
-

Synonyms

Synonyms Comment Organism
NSD2
-
 Homo sapiens
NSD3
-
 Homo sapiens