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Literature summary for 2.1.1.356 extracted from

  • Friedman, J.; Cho, W.K.; Chu, C.K.; Keedy, K.S.; Archin, N.M.; Margolis, D.M.; Karn, J.
    Epigenetic silencing of HIV-1 by the histone H3 lysine 27 methyltransferase enhancer of Zeste 2 (2011), J. Virol., 85, 9078-9089 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.356

Inhibitors

Inhibitors Comment Organism Structure
3-deazaneplanocin A
-
 Human immunodeficiency virus 1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine27 Human immunodeficiency virus 1 overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine27 Human immunodeficiency virus 1
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine27 Human immunodeficiency virus 1
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine27 Human immunodeficiency virus 1
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine27
-
 ?

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine27 overall reaction Human immunodeficiency virus 1 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine27
-
 Human immunodeficiency virus 1 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine27
-
 Human immunodeficiency virus 1 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine27
-
 Human immunodeficiency virus 1 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine27
-
 ?

Synonyms

Synonyms Comment Organism
EZH2 gene name, enhancer of zeste 2 Human immunodeficiency virus 1
Polycomb repressive complex 2
-
 Human immunodeficiency virus 1
PRC2
-
 Human immunodeficiency virus 1

General Information

General Information Comment Organism
malfunction enzyme knockdown sensitizes latent proviruses to external stimuli, such as T-cell receptor stimulation, and slows the reversion of reactivated proviruses to latency Human immunodeficiency virus 1