Literature summary for 2.1.1.356 extracted from

Stepanik, V.A.; Harte, P.J.
A mutation in the E(Z) methyltransferase that increases trimethylation of histone H3 lysine 27 and causes inappropriate silencing of active Polycomb target genes (2012), Dev. Biol., 364, 249-258.

Search for more literature for 2.1.1.356

Protein Variants

Protein Variants	Comment	Organism
additional information	the E(z)Trm mutation increases the histone H3 (K27) trimethylation efficiency of catalytic subunit E(Z) of Polycomb Repressive Complex 2	Drosophila melanogaster

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
embryo	-	Drosophila melanogaster	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + histone H3(K27)	Drosophila Polycomb Repressive Complex 2 is a lysine methyltransferase that trimethylates histone H3 (K27)	Drosophila melanogaster	?	-	?

Synonyms

Synonyms	Comment	Organism
Polycomb repressive complex 2	-	Drosophila melanogaster
PRC2	-	Drosophila melanogaster

General Information

General Information	Comment	Organism
malfunction	mutations in the catalytic subunit E(Z) that abolish methyltransferase activity disrupt Polycomb silencing, causing derepression of Polycomb target genes in cells where they are normally silenced. Increased histone H3(K27) trimethylation activity of mutant E(Z)Trm causes the premature accumulation of trimethylated histone H3(K27) in early embryogenesis, predestining initially active Polycomb target genes to silencing once Polycomb silencing is initiated	Drosophila melanogaster

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Release 2023.1 (January 2023)