Literature summary for 2.1.1.354 extracted from

Mersman, D.P.; Du, H.N.; Fingerman, I.M.; South, P.F.; Briggs, S.D.
Charge-based interaction conserved within histone H3 lysine 4 (H3K4) methyltransferase complexes is needed for protein stability, histone methylation, and gene expression (2012), J. Biol. Chem., 287, 2652-2665.

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Protein Variants

Protein Variants	Comment	Organism
additional information	the removal of the WD40 domain-containing subunits Swd1 and Swd3 of the complex of proteins associated with Set1, which contribute to the stability of Set1, leads to a loss of Set1 protein and consequently a complete loss of histone H3(K4) methylation	Saccharomyces cerevisiae

General Stability

General Stability	Organism
proteins Swd1 and Swd3 do not impact the transcriptional levels of SET1 but are important to mediate proper Set1 protein levels or stability likely by directly interacting with Set1. Acidic and basic patch interaction between Set1 and Swd1 is essential for proper Set1 protein levels	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + histone H3(K4)	-	Saccharomyces cerevisiae	?	-	?

Synonyms

Synonyms	Comment	Organism
COMPASS	the yeast H3K4 methyltransferase complex, Set1 complex or complex of proteins associated with Set1 (COMPASS), consists of Set1 and conserved Set1-associated proteins: Swd1, Swd2, Swd3, Spp1, Bre2, Sdc1, and Shg1	Saccharomyces cerevisiae
H3K4 methyltransferase	-	Saccharomyces cerevisiae
histone H3 lysine 4 methyltransferase	-	Saccharomyces cerevisiae
SET1	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)