Literature summary for 2.1.1.354 extracted from

Lee, J.; Kim, D.H.; Lee, S.; Yang, Q.H.; Lee, D.K.; Lee, S.K.; Roeder, R.G.; Lee, J.W.
A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4 (2009), Proc. Natl. Acad. Sci. USA, 106, 8513-8518.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + histone H3(K4)	ASCOM-MLL3 and ASCOM-MLL4 function as redundant but crucial histone H3(K4)-trimethylating coactivator complexes for p53	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
histone H3-lysine-4 methyltransferase	-	Mus musculus
MLL3	part of the activating signal cointegrator-2 complex	Mus musculus
MLL4	part of the activating signal cointegrator-2 complex	Mus musculus

General Information

General Information	Comment	Organism
malfunction	targeted inactivation of MLL3 H3K4 methyltransferase activity in the mouse causes ureter epithelial tumors, about 50% of MLL-deficient mice display unusual hyperproliferation and tumors in the innermost layer of ureter cells located close to the renal pelvis	Mus musculus

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Release 2023.1 (January 2023)