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Literature summary for 2.1.1.354 extracted from
- CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex (2005), J. Biol. Chem., 280, 41725-41731.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| into the pEGFP-C2 vector | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CXXC finger protein 1 | restricts the activity of the Set1 histone methyltransferase complex | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | GFP-Set1 fusion protein in nuclear speckles that are largely excluded from DAPI-bright regions, thus euchromatin localization, FLAG-CXXC finger protein 1 and GFP-Set1 colocalize to sub-nuclear regions that are distinct from regions of DAPIbright heterochromatin | Homo sapiens | 5634 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 450000 | - |
Western analysis of Set1/CXXC finger protein 1 complex | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O15047 | - |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryonic stem cell | lacking CXXC finger protein 1, cells show elevated levels of methylated histone H3-Lys4 and reduced levels of methylated histone H3-Lys9 | Mus musculus | - |
| HEK-293 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Set1/CXXC finger protein 1 complex transfers tritiated methyl groups onto both purified core histones and recombinant histone H3, fails to catalyze methylation of histone H4, specificity for histone H3-Lys4 methylation | Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| set1 histone H3-Lys4 methyltransferase complex | - |
Mus musculus |
| set1 histone H3-Lys4 methyltransferase complex | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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