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Literature summary for 2.1.1.354 extracted from
- Structures of SET domain proteins: protein lysine methyltransferases make their mark (2002), Cell, 111, 5-7.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + histone L-lysine | Homo sapiens | - |
S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
SET9, also called SET7 | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | enzyme is encoded on genes containing the SET-domain sequence, substrate specificity is connected to SET sequence | Homo sapiens | |
| S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | SET structure | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + histone L-lysine | - |
Homo sapiens | S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | - |
? | |
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