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Literature summary for 2.1.1.352 extracted from

  • Li, Y.; Smolke, C.
    Engineering biosynthesis of the anticancer alkaloid noscapine in yeast (2016), Nat. Commun., 7, 12137 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine Papaver somniferum this activity is part of the noscapine biosynthesis pathway S-adenosyl-L-homocysteine + 3-O-acetylpapaveroxine
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Organism

Organism UniProt Comment Textmining
Papaver somniferum I3PLQ6 I3PLQ6: 4'-O-desmethyl-3-O-acetylpapaveroxine O-methyltransferase subunit MT2, I3PLQ7: 4'-O-desmethyl-3-O-acetylpapaveroxine O-methyltransferase subunit MT3
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine this activity is part of the noscapine biosynthesis pathway Papaver somniferum S-adenosyl-L-homocysteine + 3-O-acetylpapaveroxine
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S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine 3-O-acetyl-4'-O-demethylpapaveroxine i.e. 6-[(S)-acetoxy[(5R)-4-hydroxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]methyl]-2,3-dimethoxybenzaldehyde. 3-O-Acetylpapaveroxine i.e. 6-[(S)-acetoxy[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]methyl]-2,3-dimethoxybenzaldehyde Papaver somniferum S-adenosyl-L-homocysteine + 3-O-acetylpapaveroxine
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General Information

General Information Comment Organism
metabolism this activity is part of the noscapine biosynthesis pathway Papaver somniferum