Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.351 extracted from

  • Mo, X.; Gui, C.; Wang, Q.
    Elucidation of a carboxylate O-methyltransferase NcmP in nocamycin biosynthetic pathway (2017), Bioorg. Med. Chem. Lett., 27, 4431-4435 .
    View publication on PubMed
Search for more literature for 2.1.1.351

Cloned(Commentary)

Cloned (Comment) Organism
heterologously expressed in Escherichia coli BL21 (DE3) Saccharothrix syringae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + nocamycin E Saccharothrix syringae the enzyme is involved in the biosynthesis of nocamycin I and nocamycin II, which both show antimicrobial activity. Compared to nocamycin I, nocamycin E shows inferior antibacterial activity, indicating the methyl group is essential to antibacterial activity S-adenosyl-L-homocysteine + nocamycin I
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharothrix syringae A0A1X9WEP1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + nocamycin E the enzyme is involved in the biosynthesis of nocamycin I and nocamycin II, which both show antimicrobial activity. Compared to nocamycin I, nocamycin E shows inferior antibacterial activity, indicating the methyl group is essential to antibacterial activity Saccharothrix syringae S-adenosyl-L-homocysteine + nocamycin I
-
 ?
S-adenosyl-L-methionine + nocamycin E nocamycin E i.e. (2R,3S,3aS,5R,6R,7S,9aS)-5-[(2R,3E,5E)-7-hydroxy-4-methyl-7-(2,4-dioxopyrroliden-3-ylidene)hepta-3,5-dien-2-yl]-2,6,9a-trimethyl-8-oxooctahydro-3a,7-epoxyfuro[3,2-b]oxocine-3-carboxylate. Nocamycin I i.e. methyl (2R,3S,3aS,5R,6R,7S,9aS)-5-[(2R,3E,5E)-7-hydroxy-4-methyl-7-(2,4-dioxopyrroliden-3-ylidene)hepta-3,5-dien-2-yl]-2,6,9a-trimethyl-8-oxooctahydro-3a,7-epoxyfuro[3,2-b]oxocine-3-carboxylate Saccharothrix syringae S-adenosyl-L-homocysteine + nocamycin I
-
 ?

Synonyms

Synonyms Comment Organism
ncmP
-
 Saccharothrix syringae

General Information

General Information Comment Organism
metabolism the enzyme is involved in the biosynthesis of nocamycin I and nocamycin II Saccharothrix syringae