Literature summary for 2.1.1.348 extracted from

Wang, H.; Hu, X.; Huang, M.; Liu, J.; Gu, Y.; Ma, L.; Zhou, Q.; Cao, X.
Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation (2019), Nat. Commun., 10, 1898 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8C3P7	-	-

Synonyms

Synonyms	Comment	Organism
METTL3	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	specific depletion of Mettl3 in dendritic cell results in impaired phenotypic and functional maturation of dendritic cells, with decreased expression of costimulatory molecules CD40, CD80 and cytokine IL-12, and reduced ability to stimulate T cell responses both in vitro and in vivo	Mus musculus
physiological function	Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation and function. Role for Mettl3-mediated m6A modification in increasing translation of certain immune transcripts for physiological promotion of dendritic cell activation and dendritic cell-based T cell response. Mettl3-mediated m6A of CD40, CD80 and TLR4 signaling adaptor Tirap transcripts enhances their translation in dendritic cells for stimulating T cell activation, and strengthening TLR4/NF-kappaB signaling-induced cytokine production	Mus musculus

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Release 2023.1 (January 2023)