Literature summary for 2.1.1.348 extracted from

Yu, J.; Shen, L.; Liu, Y.; Ming, H.; Zhu, X.; Chu, M.; Lin, J.
The m6A methyltransferase METTL3 cooperates with demethylase ALKBH5 to regulate osteogenic differentiation through NF-kappaB signaling (2020), Mol. Cell. Biochem., 463, 203-210 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q86U44	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
mesenchymal stem cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
METTL3	-	Homo sapiens

General Information

General Information	Comment	Organism
drug target	METTL3 may be an effective therapeutic target for bone tissue repair and regeneration	Homo sapiens
physiological function	the enzyme (METTL3) cooperates with demethylase ALKBH5 to regulate osteogenic differentiation through NF-kappaB signaling. METTL3 positively regulates expression of MYD88, a critical upstream regulator of NF-kappaB signaling, by facilitating m6A methylation modification to MYD88-RNA, subsequently inducing the activation of NF-kappaB, a repressor of osteogenesis, and therefore suppressing osteogenic progression. The METTL3-mediated m6A methylation is dynamically reversed by the demethylase ALKBH5	Homo sapiens

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Release 2023.1 (January 2023)