Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.348 extracted from

  • Selberg, S.; Blokhina, D.; Aatonen, M.; Koivisto, P.; Siltanen, A.; Mervaala, E.; Kankuri, E.; Karelson, M.
    Discovery of small molecules that activate RNA methylation through cooperative binding to the METTL3-14-WTAP complex active site (2019), Cell Rep., 26, 3762-3771 .
    View publication on PubMed
Search for more literature for 2.1.1.348

Activating Compound

Activating Compound Comment Organism Structure
methyl 6-methylpiperidine-3-carboxylate
-
 Homo sapiens
methyl piperazine-2-carboxylate potent activator Homo sapiens
methyl piperidine-3-carboxylate
-
 Homo sapiens
tert-butyl 6-methylpiperidine-3-carboxylate
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
S-adenosyl-L-homocysteine
-
 Homo sapiens
sinefungin
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86U44
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00236
-
 pH and temperature not specified in the publication Homo sapiens sinefungin
0.281
-
 pH and temperature not specified in the publication Homo sapiens S-adenosyl-L-homocysteine

General Information

General Information Comment Organism
drug target activators of METTL3-14-WTAP can be potential anticancer agents against glioblastoma Homo sapiens