Literature summary for 2.1.1.348 extracted from

Woodcock, C.; Yu, D.; Hajian, T.; Li, J.; Huang, Y.; Dai, N.; Correa, I.J.; Wu, T.; Vedadi, M.; Zhang, X.; Cheng, X.
Human MettL3-MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro (2019), Cell Discov., 5, 63 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q86U44 and Q9HCE5	Q86U44: METTL3, N6-adenosine-methyltransferase 70 kDa subunit. Q9HCE5: METTL14, N6-adenosine-methyltransferase non-catalytic subunit	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + adenine in mRNA	MettL3-MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro	Homo sapiens	S-adenosyl-L-homocysteine + N6-methyladenine in mRNA	-	?

Synonyms

Synonyms	Comment	Organism
MettL3-MettL14 complex	-	Homo sapiens

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Release 2023.1 (January 2023)