Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | nuclear speckles. Protein WTAP is required for nuclear speckle localization of METTL3 and METTL14 | Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | F1R777 | subunit METTL3 | - |
Homo sapiens | Q86U44 and Q9HCE5 | Q86U44 i.e. catalytic subunit METTL3, Q9HCE5 i.e non-catalytic subunit METTL14 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | in WTAP- and METTL3 intronic binding clusters, the RNA motifs AGGACU and UGUGGACU are enriched. The highest scoring motif found in both WTAP- and METTL3-binding clusters is UUAGGACU. In addition, AGGAC, UGGAC, and AGACUAA are also highly enriched in WTAP, METTL3 and WTAP/METTL3 overlay clusters, respectively | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
METTL3 | - |
Danio rerio |
General Information | Comment | Organism |
---|---|---|
physiological function | morpholino-mediated knockdown targeting Wilms' tumor 1-associating protein WTAP and/or METTL3 in zebrafish embryos causes tissue differentiation defects and increases apoptosis | Danio rerio |
physiological function | Wilms' tumor 1-associating protein (WTAP) interacts with METTL3 and METTL14, and is required for their localization into nuclear speckles enriched with pre-mRNA processing factors and for catalytic activity of the m6A methyltransferase in vivo. In the absence of WTAP, the RNA-binding capability of METTL3 is strongly reduced. In addition, WTAP and METTL3 regulate expression and alternative splicing of genes involved in transcription and RNA processing | Homo sapiens |