Literature summary for 2.1.1.348 extracted from

Yue, Y.; Liu, J.; He, C.
RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation (2015), Genes Dev., 29, 1343-1355 .

Search for more literature for 2.1.1.348

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	-	-	-
Danio rerio	-	-	-
Drosophila melanogaster	-	-	-
Mus musculus	-	-	-
Saccharomyces cerevisiae	-	-	-

Synonyms

Synonyms	Comment	Organism
ALKBH5	-	Mus musculus
FTO	-	Mus musculus
IME4	-	Drosophila melanogaster
IME4	-	Saccharomyces cerevisiae
METTL14	-	Mus musculus
METTL14	-	Danio rerio
METTL3	-	Mus musculus
METTL3	-	Danio rerio
MTA	-	Arabidopsis thaliana
YTHDF2	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	depletion of isoforms METTL3 and METTL14 leads to apoptosis in cancer cells	Mus musculus
physiological function	isoforms METTL3 and METTL4 are required for normal embryogenesis	Danio rerio
physiological function	isoforms METTL3 and METTL4 regulate stem cell differentiation and reprogramming. Isoform METTL3 regulates circadian periods	Mus musculus
physiological function	the enzyme is essential for viability and required for Notch signaling during oogenesis	Drosophila melanogaster
physiological function	the enzyme is required for embryonic development , normal growth patterns, apical dominance, and plant development	Arabidopsis thaliana
physiological function	the enzyme is required for meiosis and sporulation	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)