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Literature summary for 2.1.1.346 extracted from

  • Shimba, S.; Bokar, J.A.; Rottman, F.; Reddy, R.
    Accurate and efficient N-6-adenosine methylation in spliceosomal U6 small nuclear RNA by HeLa cell extract in vitro (1995), Nucleic Acids Res., 23, 2421-2426 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.346

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
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 Homo sapiens 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + adenine-43 in U6 snRNA Homo sapiens
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 S-adenosyl-L-homocysteine + N6-methyladenine-43 in U6 snRNA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86W50
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information U6 snRNA lacking the stem-loop near the 5' end is as efficient a substrate as the full-length U6 snRNA. U6 snRNA(41-106) is not methylated efficiently. Deletion of 19 nucleotides of the 3' end stem-loop structure (U6 snRNA(1-88)) reduces the efficiency to 20-45% of the wild-type, and U6 snRNA(1-67) does not serves as substrate at all Homo sapiens ?
-
 ?
S-adenosyl-L-methionine + adenine-43 in U6 snRNA
-
 Homo sapiens S-adenosyl-L-homocysteine + N6-methyladenine-43 in U6 snRNA
-
 ?

Synonyms

Synonyms Comment Organism
METTL16
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 Homo sapiens