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Literature summary for 2.1.1.346 extracted from

  • Pendleton, K.E.; Chen, B.; Liu, K.; Hunter, O.V.; Xie, Y.; Tu, B.P.; Conrad, N.K.
    The U6 snRNA m6A methyltransferase METTL16 regulates SAM synthetase intron retention (2017), Cell, 169, 824-835.e14 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + adenine in MAT2A hairpin 1 Homo sapiens
-
 S-adenosyl-L-homocysteine + N6-methyladenine in MAT2A hairpin 1
-
 ?
S-adenosyl-L-methionine + adenine in U6 snRNA Homo sapiens
-
 S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86W50
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + adenine in MAT2A hairpin 1
-
 Homo sapiens S-adenosyl-L-homocysteine + N6-methyladenine in MAT2A hairpin 1
-
 ?
S-adenosyl-L-methionine + adenine in U6 snRNA
-
 Homo sapiens S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA
-
 ?

Synonyms

Synonyms Comment Organism
METTL16
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme is required for induction of MAT2A splicing Homo sapiens