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Literature summary for 2.1.1.321 extracted from

  • Haghandish, N.; Baldwin, R.M.; Morettin, A.; Dawit, H.T.; Adhikary, H.; Masson, J.Y.; Mazroui, R.; Trinkle-Mulcahy, L.; Cote, J.
    PRMT7 methylates eukaryotic translation initiation factor 2alpha and regulates its role in stress granule formation (2019), Mol. Biol. Cell, 30, 778-793 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.321

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + [eukaryotic translation initiation factor 2alpha]-L-arginine Homo sapiens PRMT7 methylates eukaryotic translation initiation factor 2alpha (eIF2alpha) and regulates its role in stress granule formation S-adenosyl-L-homocysteine + [eukaryotic translation initiation factor 2alpha]-Nomega-methyl-L-arginine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NVM4
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + [eukaryotic translation initiation factor 2alpha]-L-arginine PRMT7 methylates eukaryotic translation initiation factor 2alpha (eIF2alpha) and regulates its role in stress granule formation Homo sapiens S-adenosyl-L-homocysteine + [eukaryotic translation initiation factor 2alpha]-Nomega-methyl-L-arginine
-
 ?
S-adenosyl-L-methionine + [eukaryotic translation initiation factor 2alpha]-L-arginine PRMT7 methylates eukaryotic translation initiation factor 2alpha (eIF2alpha) within an RXR motif and regulates its role in stress granule formation Homo sapiens S-adenosyl-L-homocysteine + [eukaryotic translation initiation factor 2alpha]-Nomega-methyl-L-arginine
-
 ?

Synonyms

Synonyms Comment Organism
PRMT7
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction stress granule formation, in the face of eIF2alpha-dependent cellular stresses, is significantly diminished in PRMT7-knockdown Homo sapiens
physiological function PRMT7 methylates eukaryotic translation initiation factor 2alpha and regulates its role in stress granule formation Homo sapiens