Literature summary for 2.1.1.321 extracted from

Baldwin, R.M.; Haghandish, N.; Daneshmand, M.; Amin, S.; Paris, G.; Falls, T.J.; Bell, J.C.; Islam, S.; Cote, J.
Protein arginine methyltransferase 7 promotes breast cancer cell invasion through the induction of MMP9 expression (2015), Oncotarget, 6, 3013-3032.

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Application

Application	Comment	Organism
medicine	isoform PRMT7 expression is significantly upregulated in both primary breast tumour tissues and in breast cancer lymph node metastases. Reducing PRMT7 levels in invasive breast cancer cells using RNA interference significantly decreases cell invasion in vitro and metastasis in vivo. Overexpression of PRMT7 in non-aggressive MCF-7 cells enhances their invasiveness. PRMT7 induces the expression of matrix metalloproteinase MMP9. Invasion of aggressive breast cancer cells depleted of PRMT7 may be rescued by the exogenous expression of MMP9	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NVM4	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
BT-20 cell	-	Homo sapiens	-
BT-549 cell	-	Homo sapiens	-
HEK-293T cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	isoform PRMT7 expression is significantly upregulated in both primary breast tumour tissues and in breast cancer lymph node metastases	up

General Information

General Information	Comment	Organism
physiological function	reducing PRMT7 levels in invasive breast cancer cells using RNA interference significantly decreases cell invasion in vitro and metastasis in vivo. Overexpression of PRMT7 in non-aggressive MCF-7 cells enhances their invasiveness. PRMT7 induces the expression of matrix metalloproteinase MMP9. Invasion of aggressive breast cancer cells depleted of PRMT7 may be rescued by the exogenous expression of MMP9	Homo sapiens

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Release 2023.1 (January 2023)