Literature summary for 2.1.1.321 extracted from

Ying, Z.; Mei, M.; Zhang, P.; Liu, C.; He, H.; Gao, F.; Bao, S.
Histone arginine methylation by PRMT7 controls germinal center formation via regulating Bcl6 transcription (2015), J. Immunol., 195, 1538-1547.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q922X9	-	-

General Information

General Information	Comment	Organism
physiological function	loss of PRMT7 leads to decreased mature marginal zone B cells and increased follicular B cells and promotes germinal center formation after immunization. Mice lacking PRMT7 expression in B cells secrete low levels of IgG1 and IgA. Conditional knockout mice show abnormal expression of germinal center genes (i.e., Bcl6, Prdm1, and Irf4).Overexpression of PRMT7 in the Raji and A20 cell lines derived from B cell lymphomas negatively regulates Bcl6 expression. PRMT7 can recruit histone H4R3me1 and symmetric H4R3me2 to the Bcl6 promoter	Mus musculus

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Release 2023.1 (January 2023)