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Literature summary for 2.1.1.320 extracted from

  • Jain, K.; Jin, C.; Clarke, S.
    Epigenetic control via allosteric regulation of mammalian protein arginine methyltransferases (2017), Proc. Natl. Acad. Sci. USA, 114, 10101-10106 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.320

Activating Compound

Activating Compound Comment Organism Structure
PRMT7 PRMT7-mediated monomethylation of histone H4 Arg17 regulates PRMT5 activity at Arg3 in the same protein. Monomethylation at Arg-17 in histone H4 raises the general activity of PRMT5 with this substrate, but also ameliorates the low activity of PRMT5 at low substrate concentrations Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 S-adenosyl-L-methionine + [histone H4R3]-L-arginine Homo sapiens the enzyme (PRMT5) affects the levels of symmetric dimethylarginine at Arg3 on histone H4, leading to the repression of genes which are related to disease progression in lymphoma and leukemia. PRMT7-mediated monomethylation of histone H4 Arg17 regulates PRMT5 activity at Arg3 in the same protein 2 S-adenosyl-L-homocysteine + [histone H4R3]-Nomega,Nomega'-dimethyl-L-arginine
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O14744
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + [histone H4R3]-L-arginine
-
 Homo sapiens 2 S-adenosyl-L-homocysteine + [histone H4R3]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?
2 S-adenosyl-L-methionine + [histone H4R3]-L-arginine the enzyme (PRMT5) affects the levels of symmetric dimethylarginine at Arg3 on histone H4, leading to the repression of genes which are related to disease progression in lymphoma and leukemia. PRMT7-mediated monomethylation of histone H4 Arg17 regulates PRMT5 activity at Arg3 in the same protein Homo sapiens 2 S-adenosyl-L-homocysteine + [histone H4R3]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?

Synonyms

Synonyms Comment Organism
PRMT5
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 Homo sapiens