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Literature summary for 2.1.1.320 extracted from

  • Fan, Z.; Kong, X.; Xia, J.; Wu, X.; Li, H.; Xu, H.; Fang, M.; Xu, Y.
    The arginine methyltransferase PRMT5 regulates CIITA-dependent MHC II transcription (2016), Biochim. Biophys. Acta, 1859, 687-696 .
    View publication on PubMed
Search for more literature for 2.1.1.320

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 S-adenosyl-L-methionine + [histone H3R2]-L-arginine Homo sapiens
-
 2 S-adenosyl-L-homocysteine + [histone H3R2]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?
2 S-adenosyl-L-methionine + [histone H3R2]-L-arginine Mus musculus
-
 2 S-adenosyl-L-homocysteine + [histone H3R2]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O14744
-
-
Mus musculus Q8CIG8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
RAW-264.7 cell
-
 Mus musculus
-
THP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + [histone H3R2]-L-arginine
-
 Homo sapiens 2 S-adenosyl-L-homocysteine + [histone H3R2]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?
2 S-adenosyl-L-methionine + [histone H3R2]-L-arginine
-
 Mus musculus 2 S-adenosyl-L-homocysteine + [histone H3R2]-Nomega,Nomega'-dimethyl-L-arginine
-
 ?

Synonyms

Synonyms Comment Organism
PRMT5
-
 Homo sapiens
PRMT5
-
 Mus musculus

Expression

Organism Comment Expression
Homo sapiens PRMT5 expression is down-regulated in senescent and H2O2-treated macrophages rendering ineffectual induction of MHC II transcription by IFN-gamma down
Mus musculus PRMT5 expression is down-regulated in senescent and H2O2-treated macrophages rendering ineffectual induction of MHC II transcription by IFN-gamma down

General Information

General Information Comment Organism
physiological function the enzyme (PRMT5) is essential for IFN-gamma induced, CIITA-dependent MHC II transactivation by promoting histone H3R2 methylation in macrophages. Over-expression of PRMT5 potentiates IFN-gamma induced activation of MHC II transcription in an enzyme activity-dependent manner. Pathophysiologically relevant role for PRMT5 in MHC II transactivation in macrophages Homo sapiens
physiological function the enzyme (PRMT5) is essential for IFN-gamma induced, CIITA-dependent MHC II transactivation by promoting histone H3R2 methylation in macrophages. Over-expression of PRMT5 potentiates IFN-gamma induced activation of MHC II transcription in an enzyme activity-dependent manner. Pathophysiologically relevant role for PRMT5 in MHC II transactivation in macrophages Mus musculus