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Literature summary for 2.1.1.320 extracted from

  • Zhou, Z.; Sun, X.; Zou, Z.; Sun, L.; Zhang, T.; Guo, S.; Wen, Y.; Liu, L.; Wang, Y.; Qin, J.; Li, L.; Gong, W.; Bao, S.
    PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130 (2010), Cell Res., 20, 1023-1033.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus isoform PRMT5 localizes to the Golgi apparatus and forms complexes with several components involved in Golgi apparatus ribbon formation and vesicle tethering. PRMT5 interacts with the golgin GM130 Homo sapiens 5794
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Organism

Organism UniProt Comment Textmining
Homo sapiens O14744 isoform PRMT5
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Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + [golgin GM130]-L-arginine
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Homo sapiens 2 S-adenosyl-L-homocysteine + [golgin GM130]-Nomega,Nomega'-dimethyl-L-arginine overall reaction ?

General Information

General Information Comment Organism
physiological function isoform PRMT5 interacts with the golgin GM130, and depletion of PRMT5 causes defects in Golgi ribbon formation. PRMT5 methylates N-terminal arginine residues in GM130, and such arginine methylation appears critical for Golgi apparatus ribbon formation Homo sapiens