Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | isoform PRMT5 localizes to the Golgi apparatus and forms complexes with several components involved in Golgi apparatus ribbon formation and vesicle tethering. PRMT5 interacts with the golgin GM130 | Homo sapiens | 5794 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O14744 | isoform PRMT5 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 S-adenosyl-L-methionine + [golgin GM130]-L-arginine | - |
Homo sapiens | 2 S-adenosyl-L-homocysteine + [golgin GM130]-Nomega,Nomega'-dimethyl-L-arginine | overall reaction | ? |
General Information | Comment | Organism |
---|---|---|
physiological function | isoform PRMT5 interacts with the golgin GM130, and depletion of PRMT5 causes defects in Golgi ribbon formation. PRMT5 methylates N-terminal arginine residues in GM130, and such arginine methylation appears critical for Golgi apparatus ribbon formation | Homo sapiens |