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Literature summary for 2.1.1.319 extracted from

  • Yu, C.H.; Chou, C.C.; Lee, D.Y.; Khoo, K.H.; Chang, G.D.
    Target identification reveals protein arginine methyltransferase 1 is a potential target of phenyl vinyl sulfone and its derivatives (2018), Biosci. Rep., 38, BSR20171717 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Bay 11-7082 inhibits the protein arginine methyltransferase 1 (PRMT1) activity in vitro, and treatment of cells with the inhibitor causes the decline of the levels of protein asymmetric dimethylarginine catalyzed by PRMT1 Homo sapiens
Bay 11-7085 inhibits the protein arginine methyltransferase 1 (PRMT1) activity in vitro, and treatment of cells with the inhibitor causes the decline of the levels of protein asymmetric dimethylarginine catalyzed by PRMT1 Homo sapiens
phenyl vinyl sulfonate inhibits the protein arginine methyltransferase 1 (PRMT1) activity in vitro, and treatment of cells with the inhibitor causes the decline of the levels of protein asymmetric dimethylarginine catalyzed by PRMT1 Homo sapiens
phenyl vinyl sulfone inhibits the protein arginine methyltransferase 1 (PRMT1) activity in vitro, and treatment of cells with the inhibitor causes the decline of the levels of protein asymmetric dimethylarginine catalyzed by PRMT1 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 S-adenosyl-L-methionine + [histone H4R3]-L-arginine Homo sapiens
-
2 S-adenosyl-L-homocysteine + [histone H4R3]-Nomega,Nomega-dimethyl-L-arginine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + [histone H4R3]-L-arginine
-
Homo sapiens 2 S-adenosyl-L-homocysteine + [histone H4R3]-Nomega,Nomega-dimethyl-L-arginine
-
?

Synonyms

Synonyms Comment Organism
PRMT1
-
Homo sapiens
protein arginine methyltransferase 1
-
Homo sapiens