Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.314 extracted from

  • Lin, Z.; Su, X.; Chen, W.; Ci, B.; Zhang, S.; Lin, H.
    Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis (2014), J. Am. Chem. Soc., 136, 6179-6182.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.314

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] Saccharomyces cerevisiae the eukaryotic enzyme is part of the biosynthetic pathway of diphthamide. The modification is sufficient to create diphtheria toxin sensitivity 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] diphthine methyl ester i.e. 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine ?
4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] Saccharomyces cerevisiae ATCC 204508 the eukaryotic enzyme is part of the biosynthetic pathway of diphthamide. The modification is sufficient to create diphtheria toxin sensitivity 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] diphthine methyl ester i.e. 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P32469
-
-
Saccharomyces cerevisiae ATCC 204508 P32469
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] the eukaryotic enzyme is part of the biosynthetic pathway of diphthamide. The modification is sufficient to create diphtheria toxin sensitivity Saccharomyces cerevisiae 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] diphthine methyl ester i.e. 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine ?
4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] the relevant histidine of elongation factor 2 is His699 in Saccharomyces cerevisiae Saccharomyces cerevisiae 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] diphthine methyl ester i.e. 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine ?
4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] the eukaryotic enzyme is part of the biosynthetic pathway of diphthamide. The modification is sufficient to create diphtheria toxin sensitivity Saccharomyces cerevisiae ATCC 204508 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] diphthine methyl ester i.e. 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine ?
4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] the relevant histidine of elongation factor 2 is His699 in Saccharomyces cerevisiae Saccharomyces cerevisiae ATCC 204508 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2] diphthine methyl ester i.e. 2-[(3S)-3-carboxy methyl ester-3-(trimethylammonio)propyl]-L-histidine ?

Synonyms

Synonyms Comment Organism
Dph5
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
metabolism the eukaryotic enzyme is part of the biosynthetic pathway of diphthamide Saccharomyces cerevisiae