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Literature summary for 2.1.1.309 extracted from

  • White, J.; Li, Z.; Sardana, R.; Bujnicki, J.M.; Marcotte, E.M.; Johnson, A.W.
    Bud23 methylates G1575 of 18S rRNA and is required for efficient nuclear export of pre-40S subunits (2008), Mol. Cell. Biol., 28, 3151-3161.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + guanine1575 in 18S rRNA Saccharomyces cerevisiae
-
S-adenosyl-L-homocysteine + N7-methylguanine1575 in 18S rRNA
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P25627
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + guanine1575 in 18S rRNA
-
Saccharomyces cerevisiae S-adenosyl-L-homocysteine + N7-methylguanine1575 in 18S rRNA
-
?

Synonyms

Synonyms Comment Organism
BUD23
-
Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction deletion of BUD23 leads to severely impaired growth, reduced levels of the small (40S) ribosomal subunit, and a block in processing 20S rRNA to 18S rRNA, a late step in 40S maturation Saccharomyces cerevisiae
physiological function Bud23 protein, but not its methyltransferase activity, is important for biogenesis and export of the 40S subunit in yeast Saccharomyces cerevisiae